Spectrophotometric Determination of Ambroxol Hydrochloride and Its Formulations Based on Charge Transfer Complex Reaction
نویسندگان
چکیده
A rapid, sensitive and accurate spectrophotometric method for the determination of ambroxol was described in this study. The current method was developed based on charge transfer complexation of ambroxolol (AMB) with the chloranilic acid (CAA). The formed intensed Colored complex was measured at 430 nm and used for determination of AMB and its formulations.Under optimized experimental conditions Beer’s law is obeyed in the concentratin range of 5-40 μg/ml. Recovery studies were conducted by standard addition method to confirm the accuracy of the method. Molar absorptivity and Sandell’s sensitivity were calculated and the developed method was validated as per ICH guidelines. The obtained results show that the present method can be successfully applied for the determination of AMB in pure and in pharmaceutical formulations.
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